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對所有女性疾病中,最難以治療的疾病就以子宮肌腺症莫屬,由於它是生長在子宮肌肉內層的良性腫瘤,但對於想要保留子宮又希望能減少痛楚的女性來說,常常是魚與熊掌不能兼得的事。

子宮肌腺症是所有女性疾病當中最難纏的一種疾病,也是最容易影響生育的一種子宮內膜異位症,它的發生原因和其他的子宮內膜異位症其實是相同的,...

難纏但卻可以預防的子宮肌腺症問題

January 11, 2018

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葛根研究報告

1.Jin SE, Son YK, Min BS, Jung HA, Choi JS. Anti-inflammatory and antioxidant activities of constituents isolated from Pueraria lobata roots. Arch Pharm Res. 2012 May;35(5):823-37. Epub 2012 May 29.

2: Huang F, Liu K, Du H, Kou J, Liu B. Puerarin attenuates endothelial insulin resistance through inhibition of inflammatory response in an IKKβ/IRS-1-dependent manner. Biochimie. 2012 May;94(5):1143-50. Epub 2012 Feb 1.

3: Lin F, Xie B, Cai F, Wu G. Protective effect of Puerarin on β-amyloid-induced neurotoxicity in rat ippocampal neurons. Arzneimittelforschung. 2012 Apr;62(4):187-93. Epub 2012 Jan 25.

4: Zhang MY, Qiang H, Yang HQ, Dang XQ, Wang KZ. In vitro and in vivo effects of puerarin on promotion of osteoblast bone formation. Chin J Integr Med. 2012 Apr;18(4):276-82. doi: 10.1007/s11655-012-1056-4. Epub 2012 Mar 30.

5: Cho HJ, Jun HJ, Lee JH, Jia Y, Hoang MH, Shim JH, Park KH, Lee SJ. Acute Effect of High-dose Isoflavones from Pueraria lobata (Willd.) Ohwi on Lipid and Bone Metabolism in Ovariectomized Mice. Phytother Res. 2012 Mar 16.

6: Zhang YP, Shi SY, Xiong X, Chen XQ, Peng MJ. Comparative evaluation of three methods based on high-performance liquid chromatography analysis combined with a 2,2'-diphenyl-1-picrylhydrazyl assay for the rapid screening of antioxidants from Pueraria lobata flowers. Anal Bioanal Chem. 2012 Mar;402(9):2965-76.

7: Han T, Cheng G, Liu Y, Yang H, Hu YT, Huang W. In vitro evaluation of tectoridin, tectorigenin and tectorigenin sodium sulfonate on antioxidant properties. Food Chem Toxicol. 2012 Feb;50(2):409-14. Epub 2011 Nov 4.

8: Tanaka T, Tang H, Yu F, Michihara S, Uzawa Y, Zaima N, Moriyama T, Kawamura Y.Kudzu (Pueraria lobata) vine ethanol extracts improve ovariectomy-induced bone loss in female mice. J Agric Food Chem. 2011 Dec 28;59(24):13230-7. Epub 2011 Nov18.

9: Udomsuk L, Juengwatanatrakul T, Putalun W, Jarukamjorn K. Down regulation of gene related sex hormone synthesis pathway in mouse testes by miroestrol and deoxymiroestrol. Fitoterapia. 2011 Dec;82(8):1185-9. Epub 2011 Aug 11.

10: Guan Q, Guan Q, Lin T, Yin J. Preparation and pharmacokinetics of solid lipid nanoparticles loaded with pueraria flavones. J Control Release. 2011 Nov 30;152 Suppl 1:e25-6.

11: Chen R, Xue J, Xie M. Puerarin prevents isoprenaline-induced myocardial fibrosis in mice by reduction of myocardial TGF-β1 expression. J Nutr Biochem. 2011 Nov 11.

12: He K, Li X, Chen X, Ye X, Huang J, Jin Y, Li P, Deng Y, Jin Q, Shi Q, Shu H. Evaluation of antidiabetic potential of selected traditional Chinese medicines in STZ-induced diabetic mice. J Ethnopharmacol. 2011 Oct 11;137(3):1135-42.

13: Udomsuk L, Jarukamjorn K, Putalun W, Sakuma T, Kawasaki Y, Nemoto N. Modified expression of aryl hydrocarbon receptor-related genes by deoxymiroestrol, a phytoestrogen, in mouse hepatocytes in primary culture. J Ethnopharmacol. 2011 Sep 1;137(1):902-8.

14: Yang R, Wang Q, Zeng H, Qin Z, Li J, Qu L. Determination of puerarin in biological samples and its application to a pharmacokinetic study by flow-injection chemiluminescence. Luminescence. 2011 Sep-Oct;26(5):368-73.

15: Santos CN, Koffas M, Stephanopoulos G. Optimization of a heterologous pathway for the production of flavonoids from glucose. Metab Eng. 2011 Jul;13(4):392-400.

16: Lei Z, Jian-ping G, Shi-qing W, Ze-yang Z, Chao Z, Yongxiong Y. Mechanism of acid tolerance in a rhizobium strain isolated from Pueraria lobata (Willd.) Ohwi. Can J Microbiol. 2011 Jun;57(6):514-24.

17: Zhang H, Zhang L, Zhang Q, Yang X, Yu J, Shun S, Wu Y, Zeng Q, Wang T. Puerarin: a novel antagonist to inward rectifier potassium channel (IK1). Mol Cell Biochem. 2011 Jun;352(1-2):117-23.

18: Xing G, Dong M, Li X, Zou Y, Fan L, Wang X, Cai D, Li C, Zhou L, Liu J, Niu Y. Neuroprotective effects of puerarin against beta-amyloid-induced neurotoxicity in PC12 cells via a PI3K-dependent signaling pathway. Brain Res Bull. 2011 May 30;85(3-4):212-8.

19: Wong KH, Li GQ, Li KM, Razmovski-Naumovski V, Chan K. Kudzu root: traditional uses and potential medicinal benefits in diabetes and cardiovascular diseases. J Ethnopharmacol. 2011 Apr 12;134(3):584-607.

20: Bae N, Ahn T, Chung S, Oh MS, Ko H, Oh H, Park G, Yang HO. The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease. J Ethnopharmacol. 2011 Mar 24;134(2):313-22.

21: Yeo J, Kang YM, Cho SI, Jung MH. Effects of a multi-herbal extract on type 2 diabetes. Chin Med. 2011 Mar 4;6:10.

22: Yeh TS, Chan KH, Hsu MC, Liu JF. Supplementation with soybean peptides, taurine, Pueraria isoflavone, and ginseng saponin complex improves endurance exercise capacity in humans. J Med Food. 2011 Mar;14(3):219-25.

23: Udomsuk L, Jarukamjorn K, Tanaka H, Putalun W. Improved isoflavonoid production in Pueraria candollei hairy root cultures using elicitation.Biotechnol Lett. 2011 Feb;33(2):369-74.

24: Cai RL, Li M, Xie SH, Song Y, Zou ZM, Zhu CY, Qi Y. Antihypertensive effect of total flavone extracts from Puerariae Radix. J Ethnopharmacol. 2011 Jan 7;133(1):177-83.

25: Hsiang SW, Lee HC, Tsai FJ, Tsai CC, Yao CH, Chen YS. Puerarin accelerates peripheral nerve regeneration. Am J Chin Med. 2011;39(6):1207-17.

26: Liu Q, Lawrence AJ, Liang JH. Traditional Chinese medicine for treatment of alcoholism: from ancient to modern. Am J Chin Med. 2011;39(1):1-13.

27: Zhang H, Liu Y, Lao M, Ma Z, Yi X. Puerarin protects Alzheimer's disease neuronal cybrids from oxidant-stress induced apoptosis by inhibiting pro-death signaling pathways. Exp Gerontol. 2011 Jan;46(1):30-7.

28: Li J, Wang G, Liu J, Zhou L, Dong M, Wang R, Li X, Li X, Lin C, Niu Y. Puerarin attenuates amyloid-beta-induced cognitive impairment through suppression of apoptosis in rat hippocampus in vivo. Eur J Pharmacol. 2010 Dec 15;649(1-3):195-201.

29: Lee OH, Seo DH, Park CS, Kim YC. Puerarin enhances adipocyte differentiation, adiponectin expression, and antioxidant response in 3T3-L1 cells. Biofactors. 2010 Nov-Dec;36(6):459-67. doi: 10.1002/biof.119.

30: Zhu G, Wang X, Chen Y, Yang S, Cheng H, Wang N, Li Q. Puerarin protects dopaminergic neurons against 6-hydroxydopamine neurotoxicity via inhibiting apoptosis and upregulating glial cell line-derived neurotrophic factor in a rat model of Parkinson's disease. Planta Med. 2010 Nov;76(16):1820-6.

31: Zhou J, Wang H, Xiong Y, Li Z, Feng Y, Chen J. Puerarin attenuates glutamate-induced neurofilament axonal transport impairment. J Ethnopharmacol. 2010 Oct 28;132(1):150-6.

32: Lam FF, Deng SY, Ng ES, Yeung JH, Kwan YW, Lau CB, Koon JC, Zhou L, Zuo Z, Leung PC, Fung KP. Mechanisms of the relaxant effect of a danshen and gegen formulation on rat isolated cerebral basilar artery. J Ethnopharmacol. 2010 Oct 28;132(1):186-92.

33: Kim DH, Jung HA, Park SJ, Kim JM, Lee S, Choi JS, Cheong JH, Ko KH, Ryu JH. The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice. Arch Pharm Res. 2010 Oct;33(10):1685-90.

34: Choi YH, Hong SS, Shin YS, Hwang BY, Park SY, Lee D. Phenolic compounds from Pueraria lobata protect PC12 cells against Aβ-induced toxicity. Arch Pharm Res. 2010 Oct;33(10):1651-4.

35: Mun JG, Grannan MD, Lachcik PJ, Rogers RB, Yousef GG, Grace MH, Janle EM, Wu QL, Simon JE, Weaver CM, Lila MA. Tracking deposition of a 14C-radiolabeled kudzu hairy root-derived isoflavone-rich fraction into bone. Exp Biol Med (Maywood).2010 Oct;235(10):1224-35.

36: Gupta KJ, Igamberdiev AU. Kudzu invasion leads to NOx increase and ozone pollution: unraveling possible mechanisms. Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):E153; author reply E154.

37: Malaivijitnond S, Tungmunnithum D, Gittarasanee S, Kawin K, Limjunyawong N. Puerarin exhibits weak estrogenic activity in female rats. Fitoterapia. 2010 Sep; 81(6): 569-76..

38: Chung BH, Cho YL, Kim JD, Jo HS, Won MH, Lee H, Ha KS, Kwon YG, Kim YM. Promotion of direct angiogenesis in vitro and in vivo by Puerariae flos extract via activation of MEK/ERK-, PI3K/Akt/eNOS-, and Src/FAK-dependent pathways. Phytother Res. 2010 Jun;24(6):934-40.

39: Yu HH, Jung SY, Shin MK, Park R, So HS, You YO. Pueraria thunbergiana inhibits cisplatin-induced damage of HEI-OC1 auditory cells through scavenging free radicals. Phytother Res. 2010 Jun;24(6):834-9.

40: Gu L, Yang Y, Sun Y, Zheng X. Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosis. Planta Med. 2010 Apr;76(6):583-8.

41: Zheng Y, Vagal S, Zhu XX, de Waele C, Smith PF, Wang G, Zhang M, Darlington CL. The effects of the Chinese herbal medicine EMF01 on salicylate-induced tinnitus in rats. J Ethnopharmacol. 2010 Mar 24;128(2):545-8.

42: Luo CF, Yuan M, Chen MS, Liu SM, Ji H. Metabolites of puerarin identified by liquid chromatography tandem mass spectrometry: similar metabolic profiles in liver and intestine of rats. J Chromatogr B Analyt Technol Biomed Life Sci. 2010 Feb 1;878(3-4):363-70.

43: Kim NH, Kim YS, Lee YM, Jang DS, Kim JS. Inhibition of aldose reductase and xylose-induced lens opacity by puerariafuran from the roots of Pueraria lobata. Biol Pharm Bull. 2010;33(9):1605-9.

44: Hu W, Zhang Q, Yang X, Wang Y, Sun L. Puerarin inhibits adhesion molecule expression in tnf-alpha-stimulated human endothelial cells via modulation of the nuclear factor kappaB pathway. Pharmacology. 2010;85(1):27-35.

45: Zhang R, Hu Y, Yuan J, Wu D. Effects of Puerariae radix extract on the increasing intestinal permeability in rat with alcohol-induced liver injury. J Ethnopharmacol. 2009 Nov 12;126(2):207-14.

46: Weaver CM, Martin BR, Jackson GS, McCabe GP, Nolan JR, McCabe LD, Barnes S, Reinwald S, Boris ME, Peacock M. Antiresorptive effects of phytoestrogen supplements compared with estradiol or risedronate in postmenopausal women using (41)Ca methodology. J Clin Endocrinol Metab. 2009 Oct;94(10):3798-805.

47: Peng N, Prasain JK, Dai Y, Moore R, Arabshahi A, Barnes S, Carlson S, Wyss JM. Chronic dietary kudzu isoflavones improve components of metabolic syndrome in stroke-prone spontaneously hypertensive rats. J Agric Food Chem. 2009 Aug 26;57(16):7268-73.

48: Luo Y, Chen G, Li B, Ji B, Xiao Z, Yi G, Tian F. Dietary intervention with AHP, a functional formula diet, improves both serum and hepatic lipids profile in dyslipidemia mice. J Food Sci. 2009 Aug;74(6):H189-95.

49: Yuan D, Xie YY, Bai X, Wu X, Yang JY, Wu CF. Inhibitory activity of isoflavones of Pueraria flowers on nitric oxide production from lipopolysaccharide-activated primary rat microglia. J Asian Nat Prod Res. 2009 Jun;11(6):471-81.

50: Yan LP, Zhuang YL, Chan SW, Chen SL, Shi GG. Analysis of the mechanisms underlying the endothelium-dependent antivasoconstriction of puerarin in rat aorta. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jun;379(6):587-97.

51: Kim SH, Heo JH, Kim YS, Kang SS, Choi JS, Lee SM. Protective effect of daidzin against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. Phytother Res. 2009 May;23(5):701-6.

52: Tam WY, Chook P, Qiao M, Chan LT, Chan TY, Poon YK, Fung KP, Leung PC, Woo KS. The efficacy and tolerability of adjunctive alternative herbal medicine (Salvia miltiorrhiza and Pueraria lobata) on vascular function and structure in coronary patients. J Altern Complement Med. 2009 Apr;15(4):415-21.

53: Yoo SH, Perera C, Shen J, Ye L, Suh DS, Jane JL. Molecular structure of selected tuber and root starches and effect of amylopectin structure on their physical properties. J Agric Food Chem. 2009 Feb 25;57(4):1556-64.

54: Lin YJ, Hou YC, Lin CH, Hsu YA, Sheu JJ, Lai CH, Chen BH, Lee Chao PD, Wan L, Tsai FJ. Puerariae radix isoflavones and their metabolites inhibit growth and induce apoptosis in breast cancer cells. Biochem Biophys Res Commun. 2009 Jan 23;378(4):683-8.

55: Zheng P, Ji G, Ma Z, Liu T, Xin L, Wu H, Liang X, Liu J. Therapeutic effect of puerarin on non-alcoholic rat fatty liver by improving leptin signal transduction through JAK2/STAT3 pathways. Am J Chin Med. 2009;37(1):69-83.

56: Sewell RA. Response of cluster headache to kudzu. Headache. 2009 Jan;49(1):98-105.

57: Yu C, Li Y, Chen H, Yang S, Xie G. Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity. Food Chem Toxicol. 2008 Dec;46(12):3671-6.

58: Zhang HY, Liu YH, Wang HQ, Xu JH, Hu HT. Puerarin protects PC12 cells against beta-amyloid-induced cell injury. Cell Biol Int. 2008 Oct;32(10):1230-7. 

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